2026
Гурбатов С. О., Ильященко В. М., Кучмижак А. А., Шевлягин А. В., Герасимова Елена, Михайлова Лидия, Важенин Иван, Сюй Александр, Тарасенко Николай, Большаков Алексей, Ярошенко Виталий, Зюзин Михаил
Optics and Laser Technology, Q1
Статьи в журналах
December 2026
Elena Gerasimova, Stanislav Gurbatov, Lidia Mikhailova, Ivan Vazhenin, Aleksandr Shevlyagin, Vladimir Il’yaschenko, Alexander Syuy, Nikolai Tarasenko, Alexey Bolshakov, Vitaly Yaroshenko, Aleksandr Kuchmizhak, Mikhail V. Zyuzin / Silicon-germanium nanoresonators for optical hyperthermia with simultaneous real-time temperature monitoring in cells // Optics & Laser Tecnologies - 2026 - Vol. 204, Part E - Article number 116525
The integration of nanotechnology into medicine has enabled advanced therapeutic strategies, including photothermal therapy (PTT) and light-triggered drug delivery. Central to these modalities is the use of optically active nanoparticles (NPs) capable of converting light into localized heat. While silicon (Si)-based dielectric NPs offer promising biocompatibility and Raman-based nanothermometry, their limited absorption in biological transparency windows hinders the photothermal efficiency. Here, we report the chemical-free laser-assisted synthesis of alloyed all-dielectric Si1-xGex NPs that exhibit dual functionality as efficient nanoheaters and nanoscale thermometers under near-infrared (NIR) irradiation. The all-dielectric composition of the proposed Si1-xGex NPs offers enhanced NIR light-to-heat conversion efficiency and Raman-based nanothermometry empowered by Mie resonances that promote efficient light absorption and confinement, as well as reduced photothermal damage of surrounding tissues due to minimized non-radiative energy dissipation. We performed comprehensive structural, optical, and biological analyses of the Si1-xGex NPs, supported by numerical simulations, to assess the thermal performance, cytotoxicity, internalization, and intracellular heating dynamics in B16-F10 melanoma cells. Compared to pure Mie-resonant Si NPs, the as-synthesized Si–Ge suspensions demonstrated superior light-to-heat conversion at clinically relevant laser power densities while maintaining a favorable safety profile. Our results establish the alloyed Si1-xGex NPs as a promising all-dielectric platform for integrated PTT and temperature-controlled nanomedicine.
https://doi.org/10.1016/j.optlastec.2026.116525